Ontology highlight
ABSTRACT:
SUBMITTER: Yagi OK
PROVIDER: S-EPMC2362430 | biostudies-other | 1999 Feb
REPOSITORIES: biostudies-other
British journal of cancer 19990201 3-4
Expression of CDX2, a caudal-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to Cdx2 develop multiple intestinal adenomatous polyps. To clarify the role of CDX2 in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of CDX2 in 49 sporadic colorectal carcinomas and ten hereditary non-polyposis colorectal cancers (HNPCC) without microsatellite instability. None of them exhibited a mutation. We furthe ...[more]