Ontology highlight
ABSTRACT:
SUBMITTER: Blauwkamp TA
PROVIDER: S-EPMC2396397 | biostudies-other | 2008 May
REPOSITORIES: biostudies-other
Blauwkamp Timothy A TA Chang Mikyung V MV Cadigan Ken M KM
The EMBO journal 20080417 10
Both transcriptional activation and repression have essential functions in maintaining proper spatial and temporal control of gene expression. Although Wnt signalling is often associated with gene activation, we have identified several directly repressed targets of Wnt signalling in Drosophila. Here, we explore how individual Wnt target genes are specified for signal-induced activation or repression. Similar to activation, repression required binding of Armadillo (Arm) to the N terminus of TCF. ...[more]