Ontology highlight
ABSTRACT:
SUBMITTER: Forejt J
PROVIDER: S-EPMC2447315 | biostudies-other | 2003
REPOSITORIES: biostudies-other
Forejt Jiri J Vacík Tomás T Gregorová Sona S
Comparative and functional genomics 20030101 6
All of the mouse models of human trisomy 21 syndrome that have been studied so far are based on segmental trisomies, encompassing, to a varying extent, distal chromosome 16. Their comparison with one or more unrelated and non-overlapping segmental trisomies may help to distinguish the effects of specific triplicated genes from the phenotypes caused by less specific developmental instability mechanisms. In this paper, the Ts43H segmental trisomy of mouse chromosome 17 is presented as such an alte ...[more]