Circulating microRNAs as stable blood-based markers for cancer detection.
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ABSTRACT:
SUBMITTER: Mitchell PS
PROVIDER: S-EPMC2492472 | biostudies-other | 2008 Jul
REPOSITORIES: biostudies-other
Publications
Circulating microRNAs as stable blood-based markers for cancer detection.
Mitchell Patrick S PS Parkin Rachael K RK Kroh Evan M EM Fritz Brian R BR Wyman Stacia K SK Pogosova-Agadjanyan Era L EL Peterson Amelia A Noteboom Jennifer J O'Briant Kathy C KC Allen April A Lin Daniel W DW Urban Nicole N Drescher Charles W CW Knudsen Beatrice S BS Stirewalt Derek L DL Gentleman Robert R Vessella Robert L RL Nelson Peter S PS Martin Daniel B DB Tewari Muneesh M
Proceedings of the National Academy of Sciences of the United States of America 20080728 30
Improved approaches for the detection of common epithelial malignancies are urgently needed to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs (miRNAs) are small ( approximately 22 nt) regulatory RNAs that are frequently dysregulated in cancer and have shown promise as tissue-based markers for cancer classification and prognostication. We show here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity. miRNAs ...[more]
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