Ontology highlight
ABSTRACT:
SUBMITTER: Chen JF
PROVIDER: S-EPMC2542870 | biostudies-other | 2008 Feb
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20080206 6
Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. Here, we report that cardiac-specific knockout of Dicer, a gene encoding a RNase III endonuclease essential for microRNA (miRNA) processing, leads to rapidly progressive DCM, heart failure, and postnatal lethality. Dicer mutant mice show misexpression of cardiac contractile proteins and profound sarcomere disarray. Fun ...[more]