Ontology highlight
ABSTRACT:
SUBMITTER: Stojanovski D
PROVIDER: S-EPMC2568017 | biostudies-other | 2008 Oct
REPOSITORIES: biostudies-other
The Journal of cell biology 20081013 2
The biogenesis of mitochondrial intermembrane space proteins depends on specific machinery that transfers disulfide bonds to precursor proteins. The machinery shares features with protein relays for disulfide bond formation in the bacterial periplasm and endoplasmic reticulum. A disulfide-generating enzyme/sulfhydryl oxidase oxidizes a disulfide carrier protein, which in turn transfers a disulfide to the substrate protein. Current views suggest that the disulfide carrier alternates between bindi ...[more]