Ontology highlight
ABSTRACT:
SUBMITTER: Wee HJ
PROVIDER: S-EPMC2572802 | biostudies-other | 2008 Nov
REPOSITORIES: biostudies-other
Wee Hee-Jun HJ Voon Dominic Chih-Cheng DC Bae Suk-Chul SC Ito Yoshiaki Y
Blood 20080811 9
The heterodimeric transcription factor RUNX1/PEBP2-beta (also known as AML1/CBF-beta) is essential for definitive hematopoiesis. Here, we show that interaction with PEBP2-beta leads to the phosphorylation of RUNX1, which in turn induces p300 phosphorylation. This is mediated by homeodomain interacting kinase 2 (HIPK2), targeting Ser(249), Ser(273), and Thr(276) in RUNX1, in a manner that is also dependent on the RUNX1 PY motif. Importantly, we observed the in vitro disruption of this phosphoryla ...[more]