Ontology highlight
ABSTRACT:
SUBMITTER: Gajecka M
PROVIDER: S-EPMC2577863 | biostudies-other | 2008 Nov
REPOSITORIES: biostudies-other
Gajecka Marzena M Gentles Andrew J AJ Tsai Albert A Chitayat David D Mackay Katherine L KL Glotzbach Caron D CD Lieber Michael R MR Shaffer Lisa G LG
Genome research 20080902 11
Approximately one in 500 individuals carries a reciprocal translocation. Balanced translocations are usually associated with a normal phenotype unless the translocation breakpoints disrupt a gene(s) or cause a position effect. We investigated breakpoint junctions at the sequence level in phenotypically normal balanced translocation carriers. Eight breakpoint junctions derived from four nonrelated subjects with apparently balanced translocation t(1;22)(p36;q13) were examined. Additions of nucleot ...[more]