Ontology highlight
ABSTRACT:
SUBMITTER: Scorrano L
PROVIDER: S-EPMC2582901 | biostudies-other | 2008 Nov
REPOSITORIES: biostudies-other
The Journal of cell biology 20081110 4
In certain cell types, apoptosis in response to extracellular stimuli like Fas depends on a mitochondrial amplificatory loop: the apical caspase-8 cleaves and activates the BH3-only member of the Bcl-2 family BID. In turn, BID induces the release of cytochrome c from mitochondria to the cytoplasm, where it is required to fully activate effector caspases. In this issue of The Journal of Cell Biology, Gonzalvez et al. (see p. 681) show that when caspase-8 activation and production of functional BI ...[more]