Ontology highlight
ABSTRACT:
SUBMITTER: Peese KM
PROVIDER: S-EPMC2610465 | biostudies-other | 2006 Jul
REPOSITORIES: biostudies-other
Peese Kevin M KM Gin David Y DY
Journal of the American Chemical Society 20060701 27
A concise synthetic approach to the hetisine C20-diterpenoid alkaloids is reported. The total synthesis of (+/-)-nominine was accomplished in a 15-step sequence employing a dual cycloaddition strategy. Key features of the synthesis include a reversible intramolecular 4-oxidoisoquinolinium betaine dipolar cycloaddition in conjunction with a pyrrolidine-induced dienamine isomerization/Diels-Alder cascade. ...[more]