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New advances in the treatment of Clostridium difficile infection (CDI).


ABSTRACT: Clostridium difficile infections (CDI) have increased in frequency throughout the world. In addition to an increase in frequency, recent CDI epidemics have been linked to a hypervirulent C. difficile strain resulting in greater severity of disease. Although most mild to moderate cases of CDI continue to respond to metronidazole or vancomycin, refractory and recurrent cases of CDI may require alternative therapies. This review provides a brief overview of CDI and summarizes studies involving alternative antibiotics, toxin binders, probiotics, and immunological therapies that can be considered for treatment of acute and recurrent CDI in severe and refractory situations.

SUBMITTER: Hedge DD 

PROVIDER: S-EPMC2621401 | biostudies-other | 2008 Oct

REPOSITORIES: biostudies-other

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New advances in the treatment of Clostridium difficile infection (CDI).

Hedge Dennis D DD   Strain Joe D JD   Heins Jodi R JR   Farver Debra K DK  

Therapeutics and clinical risk management 20081001 5


Clostridium difficile infections (CDI) have increased in frequency throughout the world. In addition to an increase in frequency, recent CDI epidemics have been linked to a hypervirulent C. difficile strain resulting in greater severity of disease. Although most mild to moderate cases of CDI continue to respond to metronidazole or vancomycin, refractory and recurrent cases of CDI may require alternative therapies. This review provides a brief overview of CDI and summarizes studies involving alte  ...[more]

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