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Dusp-5 and Snrk-1 coordinately function during vascular development and disease.

ABSTRACT: Mitogen-activated protein kinases play an integral role in several cellular processes. To regulate mitogen-activated protein kinases, cells express members of a counteracting group of proteins called phosphatases. In this study, we have identified a specific role that one member of this family of phosphatases, dual-specific phosphatase-5 (Dusp-5) plays in vascular development in vivo. We have determined that dusp-5 is expressed in angioblasts and in established vasculature and that it counteracts the function of a serine threonine kinase, Snrk-1, which also plays a functional role in angioblast development. Together, Dusp-5 and Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1. Importantly, mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, implicating the Snrk-1-Dusp-5 signaling pathway in human disease.

SUBMITTER: Pramanik K

PROVIDER: S-EPMC2635084 | biostudies-other | 2009 Jan

REPOSITORIES: biostudies-other

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Dusp-5 and Snrk-1 coordinately function during vascular development and disease.

Pramanik Kallal K Chun Chang Zoon CZ Garnaas Maija K MK Samant Ganesh V GV Li Keguo K Horswill Mark A MA North Paula E PE Ramchandran Ramani R

Blood 20081016 5

Mitogen-activated protein kinases play an integral role in several cellular processes. To regulate mitogen-activated protein kinases, cells express members of a counteracting group of proteins called phosphatases. In this study, we have identified a specific role that one member of this family of phosphatases, dual-specific phosphatase-5 (Dusp-5) plays in vascular development in vivo. We have determined that dusp-5 is expressed in angioblasts and in established vasculature and that it counteract ...[more]

PMID: 18927432

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