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Lysophosphatidic acid in vascular development and disease.

ABSTRACT: Lysophosphatidic acid (LPA) is a small signaling lipid that is capable of stimulating a plethora of different cellular responses through the activation of its family of cognate G protein-coupled receptors. LPA mediates a wide range of biological effects in many tissue types that have been recently reviewed; however, its effects on vasculature development and function have received comparatively less examination. In this review, literature on the actions of LPA in three main aspects of vascular development (vasculogenesis, angiogenesis, and vascular maturation) is discussed. In addition, evidence for the roles of LPA signaling in the formation of secondary vascular structures, such as the blood brain barrier, is considered, consistent with significant roles for LPA signaling in vascular development, function, and disease.

SUBMITTER: Teo ST

PROVIDER: S-EPMC4307796 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

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Lysophosphatidic acid in vascular development and disease.

Teo Siew T ST Yung Yun C YC Herr Deron R DR Chun Jerold J

IUBMB life 20090801 8

Lysophosphatidic acid (LPA) is a small signaling lipid that is capable of stimulating a plethora of different cellular responses through the activation of its family of cognate G protein-coupled receptors. LPA mediates a wide range of biological effects in many tissue types that have been recently reviewed; however, its effects on vasculature development and function have received comparatively less examination. In this review, literature on the actions of LPA in three main aspects of vascular d ...[more]

PMID: 19621353

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