Ontology highlight
ABSTRACT:
SUBMITTER: Volonte D
PROVIDER: S-EPMC2645811 | biostudies-other | 2009 Feb
REPOSITORIES: biostudies-other
Volonte Daniela D Kahkonen Beth B Shapiro Steven S Di Yuanpu Y Galbiati Ferruccio F
The Journal of biological chemistry 20081222 9
Free radicals play a role in aging and age-related human diseases, including pulmonary emphysema. Cigarette smoke represents a source of oxidants and is considered an environmental hazard that causes pulmonary emphysema. Here, we show that caveolin-1 activates ataxia telangiectasia-mutated (ATM) after oxidative stress by sequestering the ATM inhibitor, the catalytic subunit of protein phosphatase 2A, into caveolar membranes. We demonstrate that cigarette smoke extracts promote stress-induced pre ...[more]