Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC2657887 | biostudies-other | 2009 Apr
REPOSITORIES: biostudies-other
Yang Yang Y Zhao Ying Y Liao Wenjuan W Yang Jing J Wu Lipeng L Zheng Zhixing Z Yu Yu Y Zhou Wen W Li Lian L Feng Jingnan J Wang Haiying H Zhu Wei-Guo WG
Neoplasia (New York, N.Y.) 20090401 4
Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis are incompletely understood. In this study, depsipeptide, a novel HDAC inhibitor, was shown to be able to induce significant apoptotic cell death in human lung cancer cells. Further study showed that Bim, a BH3-only proapoptotic protein, was significantly upregulated by depsipeptide in cancer cells, and Bim's function in deps ...[more]