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Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A.

ABSTRACT: Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.

SUBMITTER: Giroux S

PROVIDER: S-EPMC2659505 | biostudies-other | 2008 Aug

REPOSITORIES: biostudies-other

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Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A.

Giroux Simon S Bethke Axel A Fielenbach Nicole N Antebi Adam A Corey E J EJ

Organic letters 20080719 16

Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans. ...[more]

PMID: 18642835

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