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Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues.

ABSTRACT: The total syntheses of (±)-botryosphaeridione, (±)-pleodendione, (±)-hoaensieremodione, 4-epi-periconianone B, and their analogues have been accomplished for the first time. All the synthesized target compounds were screened in neural anti-inflammatory assays using LPS induced microglia cells (N9). Among them, compounds 1 and 21 were identified as potential lead compounds for further profiling.

SUBMITTER: Handore KL

PROVIDER: S-EPMC4645243 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues.

Handore Kishor L KL Jadhav Prakash D PD Hazra Bibhabasu B Basu Anirban A Reddy D Srinivasa DS

ACS medicinal chemistry letters 20150928 11

The total syntheses of (±)-botryosphaeridione, (±)-pleodendione, (±)-hoaensieremodione, 4-epi-periconianone B, and their analogues have been accomplished for the first time. All the synthesized target compounds were screened in neural anti-inflammatory assays using LPS induced microglia cells (N9). Among them, compounds 1 and 21 were identified as potential lead compounds for further profiling. ...[more]

PMID: 26617964

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