Ontology highlight
ABSTRACT:
SUBMITTER: Yang R
PROVIDER: S-EPMC2666810 | biostudies-other | 2009 Apr
REPOSITORIES: biostudies-other
Yang Runqing R Wang Xin X Li Jian J Deng Hongwen H
Bioinformatics (Oxford, England) 20081030 8
<h4>Motivation</h4>In most quantitative trait locus (QTL) mapping studies, phenotypes are assumed to follow normal distributions. Deviations from this assumption may affect the accuracy of QTL detection and lead to detection of spurious QTLs. To improve the robustness of QTL mapping methods, we replaced the normal distribution for residuals in multiple interacting QTL models with the normal/independent distributions that are a class of symmetric and long-tailed distributions and are able to acco ...[more]