Ontology highlight
ABSTRACT:
SUBMITTER: Ferrari SR
PROVIDER: S-EPMC2673244 | biostudies-other | 2009 May
REPOSITORIES: biostudies-other
Ferrari Susan R SR Grubb Jennifer J Bishop Douglas K DK
The Journal of biological chemistry 20090307 18
During homologous recombination, a number of proteins cooperate to catalyze the loading of recombinases onto single-stranded DNA. Single-stranded DNA-binding proteins stimulate recombination by coating single-stranded DNA and keeping it free of secondary structure; however, in order for recombinases to load on single-stranded-DNA-binding protein-coated DNA, the activity of a class of proteins known as recombination mediators is required. Mediator proteins coordinate the handoff of single-strande ...[more]