GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins.
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ABSTRACT:
SUBMITTER: Beigneux AP
PROVIDER: S-EPMC2674691 | biostudies-other | 2009 Apr
REPOSITORIES: biostudies-other
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GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins.
Beigneux Anne P AP Davies Brandon S J BS Bensadoun André A Fong Loren G LG Young Stephen G SG
Journal of lipid research 20081014
GPIHBP1, a small glycosylphosphatidylinositol-anchored glycoprotein, is required for the lipolytic processing of triglyceride-rich lipoproteins. GPIHBP1 knockout mice exhibit chylomicronemia, even on a low-fat diet, with plasma triglyceride levels of 3,500-5,000 mg/dl. GPIHBP1 is expressed highly in heart, adipose tissue, and skeletal muscle, the same tissues that express high levels of lipoprotein lipase (LPL). In each of these tissues, GPIHBP1 is located in capillary endothelial cells. Chinese ...[more]
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