Ontology highlight
ABSTRACT:
SUBMITTER: Karaca M
PROVIDER: S-EPMC2679208 | biostudies-other | 2009
REPOSITORIES: biostudies-other
Karaca Melis M Castel Julien J Tourrel-Cuzin Cécile C Brun Manuel M Géant Anne A Dubois Mathilde M Catesson Sandra S Rodriguez Marianne M Luquet Serge S Cattan Pierre P Lockhart Brian B Lang Jochen J Ktorza Alain A Magnan Christophe C Kargar Catherine C
PloS one 20090518 5
<h4>Background</h4>The mass of pancreatic beta-cells varies according to increases in insulin demand. It is hypothesized that functionally heterogeneous beta-cell subpopulations take part in this process. Here we characterized two functionally distinct groups of beta-cells and investigated their physiological relevance in increased insulin demand conditions in rats.<h4>Methods</h4>Two rat beta-cell populations were sorted by FACS according to their PSA-NCAM surface expression, i.e. beta(high) an ...[more]