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"Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages.

ABSTRACT: A key cell type of the resident skin immune system is the dendritic cell (DC), which in normal skin is located in two distinct microanatomical compartments: Langerhans cells (LCs), mainly in the epidermis, and dermal DCs (DDCs), in the dermis. Here, the lineage of DDCs was investigated using monoclonal antibodies and immunohistology. We provide evidence that "DDC" comprise at least two major phenotypic populations of dendritic-appearing cells, immature DC expressing CD1, CD11c and CD208; and macrophages expressing CD209, CD206, CD163, and CD68. These data suggest that dermal dendritic-appearing macrophages comprise a novel part of the innate immune response in the resident skin immune system.

SUBMITTER: Ochoa MT

PROVIDER: S-EPMC2682223 | biostudies-other | 2008 Sep

REPOSITORIES: biostudies-other

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"Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages.

Ochoa Maria Teresa MT Loncaric Anya A Krutzik Stephan R SR Becker Todd C TC Modlin Robert L RL

The Journal of investigative dermatology 20080313 9

A key cell type of the resident skin immune system is the dendritic cell (DC), which in normal skin is located in two distinct microanatomical compartments: Langerhans cells (LCs), mainly in the epidermis, and dermal DCs (DDCs), in the dermis. Here, the lineage of DDCs was investigated using monoclonal antibodies and immunohistology. We provide evidence that "DDC" comprise at least two major phenotypic populations of dendritic-appearing cells, immature DC expressing CD1, CD11c and CD208; and mac ...[more]

PMID: 18337829

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