Ontology highlight
ABSTRACT:
SUBMITTER: Takaku M
PROVIDER: S-EPMC2682881 | biostudies-other | 2009 May
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20090326 21
The RAD51 protein is a central player in homologous recombinational repair. The RAD51B protein is one of five RAD51 paralogs that function in the homologous recombinational repair pathway in higher eukaryotes. In the present study, we found that the human EVL (Ena/Vasp-like) protein, which is suggested to be involved in actin-remodeling processes, unexpectedly binds to the RAD51 and RAD51B proteins and stimulates the RAD51-mediated homologous pairing and strand exchange. The EVL knockdown cells ...[more]