Ontology highlight
ABSTRACT:
SUBMITTER: Hearst SM
PROVIDER: S-EPMC2684838 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Hearst Scoty M SM Gilder Andrew S AS Negi Sandeep S SS Davis Misty D MD George Eric M EM Whittom Angela A AA Toyota Cory G CG Husedzinovic Alma A Gruss Oliver J OJ Hebert Michael D MD
Journal of cell science 20090512 Pt 11
Cajal bodies (CBs) are nuclear structures that are thought to have diverse functions, including small nuclear ribonucleoprotein (snRNP) biogenesis. The phosphorylation status of coilin, the CB marker protein, might impact CB formation. We hypothesize that primary cells, which lack CBs, contain different phosphoisoforms of coilin compared with that found in transformed cells, which have CBs. Localization, self-association and fluorescence recovery after photobleaching (FRAP) studies on coilin pho ...[more]