Ontology highlight
ABSTRACT:
SUBMITTER: Mesnard L
PROVIDER: S-EPMC2689902 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Mesnard Laurent L Keller Alexandre C AC Michel Marie-Laure ML Vandermeersch Sophie S Rafat Cédric C Letavernier Emmanuel E Tillet Yves Y Rondeau Eric E Leite-de-Moraes Maria C MC
Journal of the American Society of Nephrology : JASN 20090521 6
Invariant natural killer T (iNKT) cells represent a particular subset of T lymphocytes capable of producing several cytokines, which exert regulatory or effector functions, following stimulation of the T cell receptor. In this study, we investigated the influence of iNKT cells on the development of experimental anti-glomerular basement membrane glomerulonephritis (anti-GBM GN). After injection of anti-GBM serum, the number of kidney iNKT cells rapidly increased. iNKT cell-deficient mice (Jalpha1 ...[more]