Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC2693458 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Wang Xinhe X Bowers Stephanie L SL Wang Fei F Pu Xin-An XA Nelson Randy J RJ Ma Jiyan J
Biochimica et biophysica acta 20090310 6
The prion protein (PrP) is essential for the pathogenesis of prion disease. PrP has been detected in the cytosol of neurons and transgenic mice expressing PrP in the cytosol (cyPrP) under a pan-neuronal promoter developed rapid cerebellar granule neuron degeneration. Yet, it remains unclear whether cyPrP is capable to cause toxicity in other neuronal populations. Here, we report that transgenic mice expressing cyPrP in the forebrain neurons developed behavioral abnormalities including clasping a ...[more]