Ontology highlight
ABSTRACT:
SUBMITTER: Lei K
PROVIDER: S-EPMC2700906 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Lei Kai K Zhang Xiaochang X Ding Xu X Guo Xue X Chen Muyun M Zhu Binggen B Xu Tian T Zhuang Yuan Y Xu Rener R Han Min M
Proceedings of the National Academy of Sciences of the United States of America 20090609 25
How the nuclei in mammalian skeletal muscle fibers properly position themselves relative to the cell body is an interesting and important cell biology question. In the syncytial skeletal muscle cells, more than 100 nuclei are evenly distributed at the periphery of each cell, with 3-8 nuclei anchored beneath the neuromuscular junction (NMJ). Our previous studies revealed that the KASH domain-containing Syne-1/Nesprin-1 protein plays an essential role in anchoring both synaptic and nonsynaptic myo ...[more]