Ontology highlight
ABSTRACT:
SUBMITTER: Cao TM
PROVIDER: S-EPMC2710949 | biostudies-other | 2009 Jul
REPOSITORIES: biostudies-other
Cao Thai M TM Thomas Alun A Wang Yuanyuan Y Tsai Schickwann S Logronio Kathryn K Shizuru Judith A JA
Blood 20090505 1
Identifying genes that regulate bone marrow (BM) engraftment may reveal molecular targets for overcoming engraftment barriers. To achieve this aim, we applied a forward genetic approach in a mouse model of nonmyeloablative BM transplantation. We evaluated engraftment of allogeneic and syngeneic BM in BALB.K and B10.BR recipients. This allowed us to partition engraftment resistance into its intermediate phenotypes, which are firstly the immune-mediated resistance and secondly the nonimmune reject ...[more]