Ontology highlight
ABSTRACT:
SUBMITTER: Ricci EP
PROVIDER: S-EPMC2731895 | biostudies-other | 2009 Aug
REPOSITORIES: biostudies-other
Ricci Emiliano P EP Mure Fabrice F Gruffat Henri H Decimo Didier D Medina-Palazon Cahora C Ohlmann Théophile T Manet Evelyne E
Nucleic acids research 20090615 15
The Epstein-Barr virus protein (EB2) allows the nuclear export of a particular subset of early and late viral RNAs derived from intronless genes. EB2 is conserved among most herpesvirus members and its presence is essential for the production of infectious particles. Here we show that, besides its role as a nuclear export factor, EB2 strongly stimulates translation of unspliced mRNAs without affecting overall cellular translation. Interestingly, this effect can be reversed by the addition of an ...[more]