Ontology highlight
ABSTRACT:
SUBMITTER: Marques-Garcia F
PROVIDER: S-EPMC2755837 | biostudies-other | 2009 Aug
REPOSITORIES: biostudies-other
Marqués-García Fernando F Ferrandiz Nuria N Fernández-Alonso Rosalía R González-Cano Laura L Herreros-Villanueva Marta M Rosa-Garrido Manuel M Fernández-García Belén B Vaque José P JP Marqués Margarita M MM Alonso María Eugenia ME Segovia José Carlos JC León Javier J Marín María C MC
The Journal of biological chemistry 20090609 32
The TP73 gene gives rise to transactivation domain-p73 isoforms (TAp73) as well as DeltaNp73 variants with a truncated N terminus. Although TAp73alpha and -beta proteins are capable of inducing cell cycle arrest, apoptosis, and differentiation, DeltaNp73 acts in many cell types as a dominant-negative repressor of p53 and TAp73. It has been proposed that p73 is involved in myeloid differentiation, and its altered expression is involved in leukemic degeneration. However, there is little evidence a ...[more]