Ontology highlight
ABSTRACT:
SUBMITTER: Stanietsky N
PROVIDER: S-EPMC2764881 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20091007 42
NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC class I proteins and are expressed in a variegated fashion. It was recently shown that TIGIT, a new protein expressed by T and NK cells binds to PVR and PVR-like receptors and inhibits T cell activity indirectly through the manipulation of DC activity. Here, we show that TIGIT is expressed by all human NK cells, that it binds PVR and PVRL2 but not PVRL3 and that it inh ...[more]