Ontology highlight
ABSTRACT:
SUBMITTER: Kojo S
PROVIDER: S-EPMC2764888 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20091007 42
Repeated injection of alpha-galactosylceramide, an agonistic ligand for natural killer T (NKT) cells, results in long-term unresponsiveness or anergy, which severely limits its clinical application. However, the molecular mechanisms leading to NKT anergy induction remain unclear. We show here that the decreased IFN-gamma production and failed tumor rejection observed in anergized NKT cells are rescued by Cbl-b deficiency. Cbl-b E3 ligase activity is critical for the anergy induction, as revealed ...[more]