Ontology highlight
ABSTRACT:
SUBMITTER: Tuncel J
PROVIDER: S-EPMC6547863 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20190415 6
Perinatal T cells broadly access nonlymphoid tissues, where they are exposed to sessile tissue antigens. To probe the outcome of such encounters, we examined the defective elimination of self-reactive clones in Aire-deficient mice. Nonlymphoid tissues were sequentially seeded by distinct waves of CD4<sup>+</sup> T cells. Early arrivers were mostly Foxp3<sup>+</sup> regulatory T (T reg) cells and metabolically active, highly proliferative conventional T cells (T conv cells). T conv cells had unus ...[more]