Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Q
PROVIDER: S-EPMC2771553 | biostudies-other | 2008 Sep
REPOSITORIES: biostudies-other
Zhang Qian Q Malik Pulkit P Pandey Deepesh D Gupta Sonali S Jagnandan Davin D Belin de Chantemele Eric E Banfi Botond B Marrero Mario B MB Rudic R Daniel RD Stepp David W DW Fulton David J R DJ
Arteriosclerosis, thrombosis, and vascular biology 20080612 9
<h4>Objective</h4>Increased formation of reactive oxygen species (ROS) has been identified as a causative factor in endothelial dysfunction by reducing NO bioavailability and uncoupling endothelial nitric oxide synthase (eNOS). However, the specific contribution of ROS to endothelial function is not well understood.<h4>Methods and results</h4>A major source of intracellular ROS is the NADPH oxidase (Nox) family of enzymes. The goal of the current study was to directly assess the contribution of ...[more]