Ontology highlight
ABSTRACT:
SUBMITTER: Tiu RV
PROVIDER: S-EPMC2773477 | biostudies-other | 2009 Nov
REPOSITORIES: biostudies-other
Tiu Ramon V RV Gondek Lukasz P LP O'Keefe Christine L CL Huh Jungwon J Sekeres Mikkael A MA Elson Paul P McDevitt Michael A MA Wang Xiao Fei XF Levis Mark J MJ Karp Judith E JE Advani Anjali S AS Maciejewski Jaroslaw P JP
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090921 31
<h4>Purpose</h4>Cytogenetics is the primary outcome predictor in acute myeloid leukemia (AML). Metaphase cytogenetics (MC) detects an abnormal karyotype in only half of patients with AML, however. Single nucleotide polymorphism arrays (SNP-A) can detect acquired somatic uniparental disomy (UPD) and other cryptic defects, even in samples deemed normal by MC. We hypothesized that SNP-A will improve detection of chromosomal defects in AML and that this would enhance the prognostic value of MC.<h4>P ...[more]