Ontology highlight
ABSTRACT:
SUBMITTER: Endo A
PROVIDER: S-EPMC2788843 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
Endo Akinori A Kitamura Naomi N Komada Masayuki M
The Journal of biological chemistry 20090813 41
The nucleolus is a subnuclear compartment with multiple cellular functions, including ribosome biogenesis. USP36 is a deubiquitylating enzyme that localizes to nucleoli and plays an essential role in regulating the structure and function of the organelle. However, how the localization of USP36 is regulated remains unknown. Here, we identified a short stretch of basic amino acids (RGKEKKIKKFKREKRR) that resides in the C-terminal region of USP36 and serves as a nucleolar localization signal for th ...[more]