Ontology highlight
ABSTRACT:
SUBMITTER: Ameyar-Zazoua M
PROVIDER: S-EPMC2788849 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
Ameyar-Zazoua Maya M Souidi Mouloud M Fritsch Lauriane L Robin Philippe P Thomas Audrey A Hamiche Ali A Percipalle Piergiorgio P Ait-Si-Ali Slimane S Harel-Bellan Annick A
The Journal of biological chemistry 20090717 41
By combining biochemical purification and mass spectrometry, we identified proteins associated with human heterochromatin protein 1alpha (HP1alpha) both in the nucleoplasm and in chromatin. Some of these are RNA-binding proteins, and among them is the protein heterogeneous nuclear ribonucleoprotein U (hnRNP U)/SAF-A, which is linked to chromatin organization and transcriptional regulation. Here, we demonstrate that hnRNP U is a bona fide HP1alpha-interacting molecule. More importantly, hnRNP U d ...[more]