Ontology highlight
ABSTRACT:
SUBMITTER: Ban R
PROVIDER: S-EPMC2788886 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20090819 41
Microtubule plus-end tracking proteins (+TIPs) control microtubule dynamics in fundamental processes such as cell cycle, intracellular transport, and cell motility, but how +TIPs are regulated during mitosis remains largely unclear. Here we show that the endogenous end-binding protein family EB3 is stable during mitosis, facilitates cell cycle progression at prometaphase, and then is down-regulated during the transition to G(1) phase. The ubiquitin-protein isopeptide ligase SIAH-1 facilitates EB ...[more]