Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders.
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ABSTRACT:
SUBMITTER: Mercier I
PROVIDER: S-EPMC2796209 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
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Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders.
Mercier Isabelle I Jasmin Jean-Francois JF Pavlides Stephanos S Minetti Carlo C Flomenberg Neal N Pestell Richard G RG Frank Philippe G PG Sotgia Federica F Lisanti Michael P MP
Laboratory investigation; a journal of technical methods and pathology 20090330 6
Here we review the clinical and translational implications of the caveolin gene family for understanding the pathogenesis of human diseases, including breast and prostate cancers, pulmonary hypertension, cardiomyopathy, diabetes, and muscular dystrophy. Detailed phenotypic analysis of caveolin knockout mice has served to highlight the crucial role of a caveolin deficiency in the pathogenesis of many human disease processes. Mutations in the human caveolin genes are associated with a number of es ...[more]
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