Ontology highlight
ABSTRACT:
SUBMITTER: Zeisel SH
PROVIDER: S-EPMC2587491 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Brain research 20080903
Choline is an essential nutrient that is critical during fetal brain development. Choline deficiency, through disturbing methyl metabolism, may alter DNA methylation and thereby influence neural precursor cell proliferation and apoptosis. This results in long term alterations in brain structure and function, specifically memory function. A recommended dietary intake for choline in humans was set in 1998, and a portion of the choline requirement can be met via endogenous de novo synthesis of phos ...[more]