Anti-CD20 monoclonal antibodies: historical and future perspectives.
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ABSTRACT:
SUBMITTER: Lim SH
PROVIDER: S-EPMC2805725 | biostudies-other | 2010 Jan
REPOSITORIES: biostudies-other
Publications
Anti-CD20 monoclonal antibodies: historical and future perspectives.
Lim Sean H SH Beers Stephen A SA French Ruth R RR Johnson Peter W M PW Glennie Martin J MJ Cragg Mark S MS
Haematologica 20090922 1
Antibodies to CD20 have confirmed the hypothesis that monoclonal reagents can be given in vivo to alleviate human diseases. The targeting of CD20 on normal, malignant and auto-immune B-lymphocytes by rituximab has demonstrated substantial benefits for patients with a variety of B-cell lymphomas, as well as some with autoimmune disorders. There has been a notable increase in the survival rates from B-cell lymphoma in the decade since anti-CD20 therapy was introduced. ...[more]
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