Ontology highlight
ABSTRACT:
SUBMITTER: Kelley R
PROVIDER: S-EPMC2814446 | biostudies-other | 2005 May
REPOSITORIES: biostudies-other
Nature biotechnology 20050501 5
Genetic interaction analysis,in which two mutations have a combined effect not exhibited by either mutation alone, is a powerful and widespread tool for establishing functional linkages between genes. In the yeast Saccharomyces cerevisiae, ongoing screens have generated >4,800 such genetic interaction data. We demonstrate that by combining these data with information on protein-protein, prote in-DNA or metabolic networks, it is possible to uncover physical mechanisms behind many of the observed ...[more]