Ontology highlight
ABSTRACT:
SUBMITTER: Blundell J
PROVIDER: S-EPMC2824441 | biostudies-other | 2010 Feb
REPOSITORIES: biostudies-other
Blundell Jacqueline J Blaiss Cory A CA Etherton Mark R MR Espinosa Felipe F Tabuchi Katsuhiko K Walz Christopher C Bolliger Marc F MF Südhof Thomas C TC Powell Craig M CM
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100201 6
Neuroligins (NLs) are a family of neural cell-adhesion molecules that are involved in excitatory/inhibitory synapse specification. Multiple members of the NL family (including NL1) and their binding partners have been linked to cases of human autism and mental retardation. We have now characterized NL1-deficient mice in autism- and mental retardation-relevant behavioral tasks. NL1 knock-out (KO) mice display deficits in spatial learning and memory that correlate with impaired hippocampal long-te ...[more]