CDNA encoding the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei.
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ABSTRACT:
SUBMITTER: Hereld D
PROVIDER: S-EPMC282617 | biostudies-other | 1988 Dec
REPOSITORIES: biostudies-other
Publications
cDNA encoding the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei.
Hereld D D Hart G W GW Englund P T PT
Proceedings of the National Academy of Sciences of the United States of America 19881201 23
VSG lipase of Trypanosoma brucei specifically cleaves the glycosyl-phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein (VSG), releasing this protein from the plasma membrane. It also cleaves similar membrane anchors on some mammalian proteins. VSG lipase may play a role in processes such as parasite differentiation or antigenic variation. We describe here the cloning and sequencing of a cDNA encoding VSG lipase from T. brucei. ...[more]
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