Ontology highlight
ABSTRACT:
SUBMITTER: Burmester JK
PROVIDER: S-EPMC282780 | biostudies-other | 1988 Dec
REPOSITORIES: biostudies-other
Burmester J K JK Wiese R J RJ Maeda N N DeLuca H F HF
Proceedings of the National Academy of Sciences of the United States of America 19881201 24
Complementary DNA clones encoding the entire rat 1,25-dihydroxyvitamin D3 receptor were isolated, and the total 423-amino acid sequence was deduced. The amino acid sequence of the rat receptor is similar but not identical to the reported human receptor sequence. The cysteine-rich DNA-binding domain is completely conserved and the steroid-binding domain is greater than 93% conserved between rat and human. The cDNA was used as a probe in blot analysis of polyadenylylated RNA to show that the 1,25- ...[more]