Ontology highlight
ABSTRACT:
SUBMITTER: Kasza A
PROVIDER: S-EPMC2829564 | biostudies-other | 2010 Feb
REPOSITORIES: biostudies-other
Kasza Aneta A Wyrzykowska Paulina P Horwacik Irena I Tymoszuk Piotr P Mizgalska Danuta D Palmer Karren K Rokita Hanna H Sharrocks Andrew D AD Jura Jolanta J
BMC molecular biology 20100206
<h4>Background</h4>MCPIP is a novel CCCH zinc finger protein described as an RNase engaged in the regulation of immune responses. The regulation of expression of the gene coding for MCPIP - ZC3H12A is poorly explored.<h4>Results</h4>Here we report that the proinflammatory cytokine IL-1beta rapidly induces the synthesis of MCPIP in primary monocyte-derived macrophages and HepG2 cells. This up-regulation takes place through the MAP kinase pathway and following activation of the transcription facto ...[more]