Ontology highlight
ABSTRACT:
SUBMITTER: Lerner TN
PROVIDER: S-EPMC2830732 | biostudies-other | 2010 Feb
REPOSITORIES: biostudies-other
Lerner Talia N TN Horne Eric A EA Stella Nephi N Kreitzer Anatol C AC
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100201 6
Adenosine A(2A) receptor antagonists are psychomotor stimulants that also hold therapeutic promise for movement disorders. However, the molecular mechanisms underlying their stimulant properties are not well understood. Here, we show that the robust increase in locomotor activity induced by an A(2A) antagonist in vivo is greatly attenuated by antagonizing cannabinoid CB(1) receptor signaling or by administration to CB(1)(-/-) mice. To determine the locus of increased endocannabinoid signaling, w ...[more]