Ontology highlight
ABSTRACT:
SUBMITTER: Prunotto M
PROVIDER: S-EPMC2831859 | biostudies-other | 2010 Mar
REPOSITORIES: biostudies-other
Prunotto Marco M Carnevali Maria Luisa ML Candiano Giovanni G Murtas Corrado C Bruschi Maurizio M Corradini Emilia E Trivelli Antonella A Magnasco Alberto A Petretto Andrea A Santucci Laura L Mattei Silvia S Gatti Rita R Scolari Francesco F Kador Peter P Allegri Landino L Ghiggeri Gian Marco GM
Journal of the American Society of Nephrology : JASN 20100211 3
Glomerular targets of autoimmunity in human membranous nephropathy are poorly understood. Here, we used a combined proteomic approach to identify specific antibodies against podocyte proteins in both serum and glomeruli of patients with membranous nephropathy (MN). We detected specific anti-aldose reductase (AR) and anti-manganese superoxide dismutase (SOD2) IgG(4) in sera of patients with MN. We also eluted high titers of anti-AR and anti-SOD2 IgG(4) from microdissected glomeruli of three biops ...[more]