Ontology highlight
ABSTRACT:
SUBMITTER: Jorgensen TN
PROVIDER: S-EPMC2841050 | biostudies-other | 2010 Jan
REPOSITORIES: biostudies-other
Jørgensen Trine N TN Alfaro Jennifer J Enriquez Hilda L HL Jiang Chao C Loo William M WM Atencio Stephanie S Bupp Melanie R Gubbels MR Mailloux Christina M CM Metzger Troy T Flannery Shannon S Rozzo Stephen J SJ Kotzin Brian L BL Rosemblatt Mario M Bono María Rosa MR Erickson Loren D LD
Journal of immunology (Baltimore, Md. : 1950) 20091216 2
Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune tolerance that leads to antinuclear Ab production. To identify gene intervals within Nba2 that control the development of autoantibody-producing B cells and to determine the cellular components through which Nba2 genes accomplish this, we generated congenic mice expressing var ...[more]