Ontology highlight
ABSTRACT:
SUBMITTER: Mahajan K
PROVIDER: S-EPMC2841635 | biostudies-other | 2010 Mar
REPOSITORIES: biostudies-other
Mahajan Kiran K Coppola Domenico D Challa Sridevi S Fang Bin B Chen Y Ann YA Zhu Weiwei W Lopez Alexis S AS Koomen John J Engelman Robert W RW Rivera Charlene C Muraoka-Cook Rebecca S RS Cheng Jin Q JQ Schönbrunn Ernst E Sebti Said M SM Earp H Shelton HS Mahajan Nupam P NP
PloS one 20100319 3
The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. Most studies have focused on its activation by Receptor Tyrosine Kinase (RTK) mediated Phosphatidylinositol-3-OH kinase (PI3K) activation or loss of Phosphatase and Tensin homolog (PTEN). We have uncovered that growth factors binding to RTKs lead to activation of a non-receptor tyrosine kinase, Ack1 (also known as ACK or TNK2), which directl ...[more]